Investigating how IL-15 affects skin cancer progression in patients with Cutaneous T-cell Lymphoma.
The Role of IL-15 in Cutaneous T-cell Lymphoma Progression
This study is looking at how a protein called IL-15 affects the growth and movement of skin cancer cells in people with Cutaneous T-cell Lymphoma, using a special mouse model to find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10891650 on NIH RePORTER |
What this research studies
This research focuses on Cutaneous T-cell Lymphoma (CTCL), a skin cancer characterized by the accumulation of abnormal T lymphocytes. The study aims to understand how a protein called interleukin-15 (IL-15) contributes to the progression of this disease. Researchers will use a special mouse model that mimics human CTCL to explore how IL-15 influences the behavior of cancerous T-cells and their movement to the skin. By uncovering these mechanisms, the research hopes to identify new treatment strategies for managing CTCL.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Cutaneous T-cell Lymphoma who are experiencing progressive skin symptoms.
Not a fit: Patients with other types of skin cancers or those without a diagnosis of Cutaneous T-cell Lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the quality of life for patients with Cutaneous T-cell Lymphoma.
How similar studies have performed: Previous research has shown promising results in understanding the role of IL-15 in other cancers, suggesting potential for success in this area as well.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mishra, Anjali — Thomas Jefferson University
- Study coordinator: Mishra, Anjali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.