Investigating how IL-10R signaling affects blood stem cells in inflammation and cancer.
Role of IL-10R signaling in inflammation induced exhaustion of HSC and emergence of JAK2V617F clonal hematopoiesis
This study is looking at how a protein called IL-10R affects blood stem cells, especially in people with blood cancers and inflammation, to find out why some of these cells become mutated and how we might develop better treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11167116 on NIH RePORTER |
What this research studies
This research focuses on understanding how the signaling of a specific protein, IL-10R, influences the behavior of blood stem cells in the context of inflammation and certain blood cancers. The study examines how chronic inflammation and age can lead to the emergence of mutated blood stem cells that may contribute to blood disorders. By analyzing patients with myeloproliferative neoplasms (MPN), the researchers aim to uncover the mechanisms behind a reduced response to IL-10, which could help identify new therapeutic strategies to combat these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a diagnosis of myeloproliferative neoplasms or those with a family history of these conditions.
Not a fit: Patients without any hematologic malignancies or those who do not have a family history of myeloproliferative neoplasms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with blood cancers by targeting the mechanisms that allow cancerous cells to thrive.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammatory signaling in blood cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Fleischman, Angela Goffredo — University of California-Irvine
- Study coordinator: Fleischman, Angela Goffredo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.