Investigating how IL-10R signaling affects blood stem cells in inflammation and cancer.
Role of IL-10R signaling in inflammation induced exhaustion of HSC and emergence of JAK2V617F clonal hematopoiesis
This study is looking at how a protein called IL-10R affects blood stem cells, especially in people with certain blood cancers and inflammation, to find out why some cells become harmful and how we might treat these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10897093 on NIH RePORTER |
What this research studies
This research focuses on understanding how the signaling of a specific protein, IL-10R, influences the behavior of blood stem cells in the context of inflammation and certain blood cancers. It examines how chronic inflammation and age can lead to the emergence of mutant blood stem cells that may contribute to blood disorders. By studying patients with myeloproliferative neoplasms (MPN), the research aims to identify the mechanisms that give these mutant cells an advantage over normal cells, potentially leading to new therapeutic strategies. The project will also explore the prevalence of an 'IL-10 resistance phenotype' in families affected by MPN.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with myeloproliferative neoplasms or those with a family history of these conditions.
Not a fit: Patients without any hematologic malignancies or those not related to individuals with MPN may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target specific blood cancers by addressing the underlying mechanisms of inflammation and stem cell behavior.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammatory signaling in blood cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Fleischman, Angela Goffredo — University of California-Irvine
- Study coordinator: Fleischman, Angela Goffredo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.