Investigating how IL-1 signaling affects heart failure
Unconventional IL-1 Signaling in Heart failure
This study is looking at how a substance called IL-1, which causes inflammation, affects heart failure and whether using IL-1 blockers can help improve heart function and reduce hospital visits for older adults with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10772005 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of inflammation, specifically through Interleukin-1 (IL-1) signaling, in the progression of heart failure (HF). It aims to explore whether targeting IL-1 can alleviate symptoms, improve heart function, and reduce hospitalizations for patients suffering from HF. By utilizing IL-1 blockers, the study seeks to determine their effectiveness in managing inflammation and restoring cardiac function in patients. The research is particularly relevant for older adults, who are disproportionately affected by heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65 years, who are experiencing symptoms of heart failure.
Not a fit: Patients with heart failure who do not have significant inflammatory responses or those with other underlying conditions that complicate treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the quality of life and outcomes for patients with heart failure.
How similar studies have performed: Previous studies have shown promising results with IL-1 blockers in reducing inflammation and improving heart function, indicating a potential for success in this approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Toldo, Stefano — University of Virginia
- Study coordinator: Toldo, Stefano
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.