Investigating how IGFBP3 affects heart regeneration in newborns
Role of IGFBP3 in Neonatal Heart Regeneration
['FUNDING_CAREER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11022013
This study is looking at how a protein called IGFBP3 helps baby mice heal their hearts after injury, with the hope that what we learn can lead to new treatments for heart problems in people.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11022013 on ClinicalTrials.gov |
What this research studies
This research explores the role of IGFBP3 in the regeneration of heart tissue in neonatal mice, aiming to understand the molecular mechanisms that allow for complete heart recovery after injury. The study is conducted at Columbia University Medical Center, where experienced mentors guide the research process. By examining how neonatal hearts can regenerate, the research seeks to translate these findings into potential therapies for heart diseases in humans. Patients may benefit from novel treatments derived from this understanding of heart regeneration.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include infants and young children with heart conditions or those at risk of cardiac diseases.
Not a fit: Patients with chronic heart conditions or those who are older than 21 years may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking therapies for heart diseases by harnessing the regenerative capabilities observed in neonatal hearts.
How similar studies have performed: Previous studies have shown promising results in understanding heart regeneration in neonatal models, suggesting that this approach could lead to significant advancements in cardiac treatment.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALI, SHAH RUKH — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: ALI, SHAH RUKH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.