Investigating how IgE interacts with Galectin-3 to activate basophils
Official title: The Role of IgE in Galectin-3-dependent Activation of Basophils
Funded at Johns Hopkins University · NIH-10996842 · Data updated 2026-11-12
This study is looking at how a protein called IgE helps certain immune cells, called basophils, react during allergies, and it aims to find out if there are differences in how IgE works in people with allergies compared to those without, which could help us understand allergic reactions better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 15, 2024 |
| Project end | July 14, 2026 |
| Funding year | 2024 |
| Award (this year) | $81,364 |
| NIH project number | 1F32AI186362-01 |
| Project ID | NIH-10996842 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with allergic conditions such as asthma or other allergic diseases.
✕Less likely to help
Patients who do not have allergies or related immune conditions may not benefit from this research.
What this research studies
This research explores the role of Immunoglobulin E (IgE) in activating basophils, a type of immune cell involved in allergic reactions. It focuses on how IgE binds to its receptor on basophils and how this interaction can lead to the release of inflammatory substances. The study also examines a novel mechanism where IgE can activate basophils independently of allergens through its interaction with Galectin-3, a sugar-binding protein. By understanding these interactions, the research aims to identify differences in IgE glycosylation patterns between allergic and non-allergic individuals, which could provide insights into allergic responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating allergic diseases.
How similar studies have gone: Other research has shown promising results in understanding IgE interactions, but this specific approach involving Galectin-3 is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Ehrlich, Laurent — Johns Hopkins University
- Study coordinator: Ehrlich, Laurent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.