Investigating how IgE interacts with Galectin-3 to activate basophils
The Role of IgE in Galectin-3-dependent Activation of Basophils
This study is looking at how a protein called IgE helps certain immune cells, called basophils, react during allergies, and it aims to find out if there are differences in how IgE works in people with allergies compared to those without, which could help us understand allergic reactions better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10996842 on NIH RePORTER |
What this research studies
This research explores the role of Immunoglobulin E (IgE) in activating basophils, a type of immune cell involved in allergic reactions. It focuses on how IgE binds to its receptor on basophils and how this interaction can lead to the release of inflammatory substances. The study also examines a novel mechanism where IgE can activate basophils independently of allergens through its interaction with Galectin-3, a sugar-binding protein. By understanding these interactions, the research aims to identify differences in IgE glycosylation patterns between allergic and non-allergic individuals, which could provide insights into allergic responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with allergic conditions such as asthma or other allergic diseases.
Not a fit: Patients who do not have allergies or related immune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating allergic diseases.
How similar studies have performed: Other research has shown promising results in understanding IgE interactions, but this specific approach involving Galectin-3 is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Ehrlich, Laurent — Johns Hopkins University
- Study coordinator: Ehrlich, Laurent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.