Investigating how IgA antibodies can block HIV-1 infection
Characterization of HIV-1 IgA bNAbs and ADCP function
This study is looking at how a special type of antibody called IgA can help protect against HIV-1 infection, especially where the virus usually enters the body, and if giving these antibodies directly can be more effective than the usual ones; if you're interested, you might be able to help by providing samples for the research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10992183 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of IgA antibodies in preventing HIV-1 infection, particularly at mucosal surfaces where the virus typically enters the body. By using a novel platform to analyze memory B cells, the researchers aim to isolate broadly neutralizing antibodies (bNAbs) that can effectively neutralize the virus. The study will also explore the potential of passive infusion of IgA antibodies to enhance protection against HIV-1 compared to traditional IgG antibodies. Patients may have the opportunity to contribute to this important work by providing samples for analysis.
Who could benefit from this research
Good fit: Ideal candidates for participation would include individuals living with HIV-1 or those at high risk of infection who can provide biological samples.
Not a fit: Patients who are not infected with HIV-1 and are not at risk for infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective strategies for preventing HIV-1 infection, particularly in high-risk populations.
How similar studies have performed: Previous research has shown promise in isolating IgG antibodies for HIV-1, but this approach focusing on IgA is relatively novel and untested.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Wu, Xueling — Columbia University Health Sciences
- Study coordinator: Wu, Xueling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.