Investigating how IDH mutations affect cell function and stress in cancer
Isocitrate dehydrogenase (IDH) mutations as drivers of organelle stress and dysfunction"
This study is looking at how changes in certain genes related to cancer, especially in people with acute myeloid leukemia, can create harmful substances in the body and cause problems, with the hope of finding new treatments for those affected by these cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10873359 on NIH RePORTER |
What this research studies
This research focuses on the impact of mutations in the isocitrate dehydrogenase (IDH) genes, which are linked to various cancers, particularly acute myeloid leukemia (AML). The study aims to understand how these mutations lead to the production of harmful metabolites that disrupt normal cellular processes and contribute to cancer progression. By exploring the relationship between IDH mutations and organelle stress, the research seeks to identify potential new drug targets and therapeutic strategies for patients with IDH-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with acute myeloid leukemia or other cancers associated with IDH mutations.
Not a fit: Patients without IDH mutations or those with cancers unrelated to IDH may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the metabolic changes caused by IDH mutations in cancer patients.
How similar studies have performed: Previous research has shown promising results in targeting IDH mutations in cancer, indicating that this approach has potential for success.
Where this research is happening
San Diego, United States
- San Diego State University — San Diego, United States (Active)
Researchers
- Principal investigator: Sohl, Christal Dyane — San Diego State University
- Study coordinator: Sohl, Christal Dyane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.