Investigating how ICAM1 influences pancreatic cancer development and progression
Role of ICAM1 in development and progression of pancreatic cancer
This study is looking at how a protein called ICAM1 affects pancreatic cancer and how it might help attract certain immune cells that can make the cancer grow, with the hope of finding new ways to treat or prevent this tough disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10560622 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of ICAM1 in pancreatic ductal adenocarcinoma (PDA), a type of pancreatic cancer with a poor prognosis. The study aims to explore how oncogenic mutations and inflammation contribute to the disease, particularly how ICAM1 attracts inflammatory macrophages that can promote tumor growth. By using animal models, researchers will investigate the mechanisms behind these processes and seek to identify potential interventions that could alter the course of the disease. The ultimate goal is to find new therapeutic strategies to prevent or treat pancreatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of cancer or those without pancreatic cancer risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Storz, Peter — Mayo Clinic Jacksonville
- Study coordinator: Storz, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.