Investigating how hypoxic conditioning can protect the brain after a subarachnoid hemorrhage.
Official title: Roles of NAMPT and NAD+ in hypoxic conditioning-induced neurovascular protection in subarachnoid hemorrhage
Funded at Washington University · NIH-10881913 · Data updated 2026-11-12
This study is looking at how controlled low-oxygen conditions might help protect the brain after a serious bleeding event called a subarachnoid hemorrhage, with the goal of finding new ways to improve recovery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $550,181 |
| NIH project number | 5R01NS128082-02 |
| Project ID | NIH-10881913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a subarachnoid hemorrhage and are within the critical time frame for intervention.
✕Less likely to help
Patients who have not experienced a subarachnoid hemorrhage or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the protective effects of hypoxic conditioning on the brain following a subarachnoid hemorrhage (SAH), a serious condition that can lead to significant brain injury. The study explores how exposing the brain to controlled low-oxygen conditions can enhance its resilience to injury, particularly in the critical days following the hemorrhage. By examining the roles of specific proteins and pathways involved in this protective mechanism, the research aims to develop new therapeutic strategies that could improve outcomes for patients suffering from SAH.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce brain injury and improve recovery for patients after a subarachnoid hemorrhage.
How similar studies have gone: Previous research has shown promising results with hypoxic conditioning in other contexts, suggesting that this approach may be effective in providing neuroprotection in cases of subarachnoid hemorrhage.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Zipfel, Gregory J — Washington University
- Study coordinator: Zipfel, Gregory J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.