Investigating how hypothalamic amenorrhea affects cardiovascular health in women.
Official title: Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health
Funded at Mayo Clinic Jacksonville · NIH-10890088 · Data updated 2026-11-12
This study is looking at how hypothalamic amenorrhea (HA), which causes missed periods and can affect fertility, relates to heart health, and it’s designed for women with HA to help us understand how this condition impacts their overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $682,692 |
| NIH project number | 5R01HD106096-05 |
| Project ID | NIH-10890088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age experiencing hypothalamic amenorrhea, particularly those with a history of stress, high physical activity, or significant weight loss.
✕Less likely to help
Patients who do not have hypothalamic amenorrhea or those with other unrelated menstrual disorders may not benefit from this research.
What this research studies
This research focuses on hypothalamic amenorrhea (HA), a condition that leads to irregular menstrual cycles and infertility in women. It aims to explore the relationship between different HA phenotypes and cardiovascular health, particularly looking at preclinical cardiovascular disease and vascular inflammation. The study will utilize innovative remote patient monitoring and patient-reported outcomes to gather data. By analyzing information from large cohort studies, the research seeks to differentiate HA from other menstrual disorders and understand its implications for overall health.
Why it matters
Potential benefit: If successful, this research could provide insights into how fertility status markers like hypothalamic amenorrhea relate to cardiovascular health, potentially leading to improved health outcomes for women.
How similar studies have gone: Previous studies have indicated a link between menstrual irregularities and cardiovascular disease, suggesting that this research builds on established findings while exploring a novel aspect of women's health.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Shufelt, Chrisandra Lee — Mayo Clinic Jacksonville
- Study coordinator: Shufelt, Chrisandra Lee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.