Investigating how hypoglossal nerve stimulation affects cognition and language in individuals with Down syndrome
Effects of Hypoglossal Nerve Stimulation on Cognition & Language in Down Syndrome
['FUNDING_U01'] · MASSACHUSETTS EYE AND EAR INFIRMARY · NIH-10905009
This study is looking at how a special device that helps with sleep apnea might improve speech and thinking skills in kids and teens with Down syndrome, so they can enjoy a better quality of life.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS EYE AND EAR INFIRMARY (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10905009 on ClinicalTrials.gov |
What this research studies
This research explores the impact of hypoglossal nerve stimulation (HGS) on cognitive and language abilities in children and adolescents with Down syndrome. The study involves implanting a device that stimulates the hypoglossal nerve to alleviate obstructive sleep apnea, which is common in this population. Participants will undergo assessments before and after the procedure to evaluate changes in their speech, language skills, and cognitive function. The goal is to determine if HGS can lead to significant improvements in these areas, thereby enhancing the quality of life for individuals with Down syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 10 to 21 with Down syndrome who experience obstructive sleep apnea.
Not a fit: Patients who do not have Down syndrome or those outside the age range of 10 to 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive and language outcomes for individuals with Down syndrome.
How similar studies have performed: Previous studies have shown promising results with hypoglossal nerve stimulation in improving obstructive sleep apnea, but this specific application in Down syndrome is still being rigorously tested.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS EYE AND EAR INFIRMARY — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARTNICK, CHRISTOPHER J — MASSACHUSETTS EYE AND EAR INFIRMARY
- Study coordinator: HARTNICK, CHRISTOPHER J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.