Investigating how hydrogen sulfide lowers eye pressure in glaucoma
Official title: MECHANISM OF IOP-LOWERING EFFECTS OF HYDROGEN SULFIDE
Funded at Texas Southern University · NIH-10114374 · Data updated 2026-11-12
This study is looking at how a gas called hydrogen sulfide might help lower eye pressure in people with glaucoma, which can help protect your vision, and it uses animal models to see how it works.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Southern University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $458,859 |
| NIH project number | 1R15EY032274-01 |
| Project ID | NIH-10114374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary open-angle glaucoma who experience elevated intraocular pressure.
✕Less likely to help
Patients with other forms of glaucoma or those who do not have elevated intraocular pressure may not benefit from this research.
What this research studies
This research explores the role of hydrogen sulfide (H2S) in lowering intraocular pressure (IOP) in glaucoma, a condition characterized by increased eye pressure that can lead to vision loss. The study will utilize animal models to evaluate how H2S affects the outflow of aqueous humor, the fluid in the eye, and to understand the underlying mechanisms involved. By administering H2S-releasing compounds, researchers aim to uncover how this gas influences eye pressure regulation and vascular function. The findings could provide insights into new treatment strategies for managing glaucoma.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively lower eye pressure in glaucoma patients, potentially preventing vision loss.
How similar studies have gone: Previous studies have shown that hydrogen sulfide can lower eye pressure in animal models, indicating potential for success in this area of research.
Where this research is happening
-
Texas Southern University
Houston, United States Active
Researchers
- Principal investigator: Mbye, Ya Fatou Njie — Texas Southern University
- Study coordinator: Mbye, Ya Fatou Njie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.