Investigating how hydrogen sulfide affects blood vessel aging
Official title: Cystathionine Gamma Lyase (CSE) and Hydrogen Sulfide Regulation of Vascular Aging
Funded at Louisiana State Univ Hsc Shreveport · NIH-10879024 · Data updated 2026-11-12
This study is looking at how a substance called CSE and a gas called hydrogen sulfide affect the health of blood vessels as we get older, with the hope of finding new ways to help older adults have healthier hearts and blood vessels.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $219,000 |
| NIH project number | 5P20GM121307-07 |
| Project ID | NIH-10879024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cardiovascular issues or those at risk due to aging.
✕Less likely to help
Patients with cardiovascular conditions unrelated to aging or those who are not elderly may not benefit from this research.
What this research studies
This research explores the role of cystathionine gamma lyase (CSE) and hydrogen sulfide (H2S) in the aging of blood vessels, which is crucial for understanding cardiovascular diseases. The study aims to uncover how deficiencies in CSE and H2S contribute to vascular dysfunction as people age. By examining the molecular mechanisms involved, the research seeks to identify potential targets for improving vascular health in older adults. Patients may benefit from insights that could lead to new treatments for age-related cardiovascular issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases associated with aging.
How similar studies have gone: While the specific role of CSE and H2S in vascular aging is still being explored, related research has shown promising results in understanding vascular health and aging.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Kolluru, Gopi K — Louisiana State Univ Hsc Shreveport
- Study coordinator: Kolluru, Gopi K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.