Investigating how hydrogen sulfide affects blood flow in pregnant women and those with preeclampsia
H2S and Uterine Vasodilation in Pregnancy and Preeclampsia
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10845284
This study is looking at how a natural gas called hydrogen sulfide can help improve blood flow to the uterus during pregnancy, which is important for the baby's growth, and it hopes to find new ways to help women who might face issues like preeclampsia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10845284 on ClinicalTrials.gov |
What this research studies
This research explores the role of hydrogen sulfide (H2S) in enhancing blood flow to the uterus during pregnancy, which is crucial for fetal development. It examines how the body produces H2S and its potential to improve uterine artery dilation, especially in cases where blood flow is insufficient, leading to complications like preeclampsia. By using animal models and clinical observations, the study aims to identify new mechanisms that support healthy pregnancy outcomes. Patients may benefit from insights that could lead to new treatments for conditions affecting blood flow during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women, particularly those at risk for preeclampsia or experiencing complications related to uterine blood flow.
Not a fit: Patients who are not pregnant or those with unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving blood flow during pregnancy, potentially reducing the risk of complications like preeclampsia.
How similar studies have performed: Previous research has indicated that targeting blood flow mechanisms during pregnancy can lead to significant improvements, suggesting this approach may hold promise.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, DONGBAO — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: CHEN, DONGBAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.