Investigating how hybrid insulin peptides contribute to type 1 diabetes
Official title: Study the role and origin of hybrid insulin peptides in the pathogenesis of type 1 diabetes
Funded at University of Colorado Denver · NIH-11088017 · Data updated 2026-11-12
This study is looking at how certain proteins called hybrid insulin peptides might play a role in the development of type 1 diabetes, using mice to see how changes in these proteins could affect the disease, with the hope of finding new ways to prevent or manage diabetes for people like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $36,538 |
| NIH project number | 5F31DK138763-02 |
| Project ID | NIH-11088017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing type 1 diabetes or those with early-stage T1D.
✕Less likely to help
Patients with type 2 diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the role of hybrid insulin peptides (HIPs) in the development of type 1 diabetes (T1D), an autoimmune condition that destroys insulin-producing cells in the pancreas. The study will utilize non-obese diabetic mice to explore how mutations affecting HIP formation can influence the progression of diabetes. By analyzing islet samples through advanced mass spectrometry, researchers aim to identify specific autoantigens that trigger the autoimmune response in T1D. This could lead to new insights into preventing or managing the disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating type 1 diabetes by targeting specific autoantigens.
How similar studies have gone: Previous research has shown promise in identifying autoantigens in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Groegler, Jason — University of Colorado Denver
- Study coordinator: Groegler, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.