Investigating how hyaluronic acid affects endometriosis
Official title: The role of hyaluronic acid and its receptors in the pathogenesis of endometriosis
Funded at University of Texas Hlth Science Center · NIH-10894459 · Data updated 2026-11-12
This study is looking at how a substance called hyaluronic acid affects the growth of endometriosis, a condition that many women experience, and it’s exploring how a specific drug might help in treating it by stopping the production of hyaluronic acid.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $299,804 |
| NIH project number | 1R56HD112451-01 |
| Project ID | NIH-10894459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age who have been diagnosed with endometriosis.
✕Less likely to help
Patients who do not have endometriosis or are not of reproductive age may not benefit from this research.
What this research studies
This research focuses on understanding the role of hyaluronic acid and its receptors in the development of endometriosis, a condition affecting many women. The study aims to explore how endometrial cells attach to other cells in the body, leading to the formation of endometriotic lesions. By examining the mechanisms involved, including the impact of a drug called Hymecromone that inhibits hyaluronic acid production, the research seeks to uncover potential therapeutic targets for treating endometriosis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for endometriosis, improving the quality of life for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of hyaluronic acid in other conditions, suggesting potential for success in this area as well.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Schenken, Robert S — University of Texas Hlth Science Center
- Study coordinator: Schenken, Robert S
Related research
Other NIH-funded projects on the same topics.
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Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
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Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.