Investigating how HuR-Wisp1 signaling affects heart tissue repair
Official title: HuR-Wisp1 signaling in cardiac fibroblasts
Funded at University of Cincinnati · NIH-10932895 · Data updated 2026-11-12
This study is looking at how certain signals in heart cells help with healing and could lead to better treatments for heart fibrosis, a condition that can make it hard for the heart to work properly, so that patients can have healthier hearts and fewer complications.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,960 |
| NIH project number | 5F31HL170636-02 |
| Project ID | NIH-10932895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that lead to cardiac fibrosis, such as hypertension or heart failure.
✕Less likely to help
Patients with non-cardiac related conditions or those without any signs of cardiac fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding the role of HuR-Wisp1 signaling in cardiac fibroblasts, which are crucial for heart tissue repair and remodeling. The study will utilize mouse models to observe how the activation of these cells contributes to heart fibrosis, a condition that can lead to heart failure. By examining the mechanisms behind this signaling pathway, the research aims to identify potential therapeutic targets that could help in managing or reversing cardiac fibrosis. Patients may benefit from insights gained about how to improve heart function and reduce fibrosis-related complications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce fibrosis in patients with heart disease.
How similar studies have gone: Previous research has shown promising results in targeting similar signaling pathways for cardiac fibrosis, indicating potential for success in this approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Parkins, Sharon — University of Cincinnati
- Study coordinator: Parkins, Sharon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.