Investigating how Huntingtin protein affects cellular processes in Huntington's disease
The role of Huntingtin in endolysosomal trafficking and Huntington's disease pathogenesis
This study is looking at how a protein called Huntingtin works with another protein to help keep brain cells healthy, which could help us understand Huntington's disease better and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11075519 on NIH RePORTER |
What this research studies
This research explores the role of the Huntingtin protein in the endolysosomal trafficking process, which is crucial for maintaining healthy neurons. By studying the interactions between Huntingtin and its partner HAP40 in a model organism, the research aims to uncover how these proteins contribute to the development of Huntington's disease. The approach involves genetic and biochemical analyses to understand the underlying mechanisms that lead to neurodegeneration. Patients may benefit from insights that could lead to new therapeutic strategies targeting these cellular pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk due to family history.
Not a fit: Patients with other neurodegenerative diseases unrelated to Huntington's disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Huntington's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular processes in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Farmer, Stephen M — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Farmer, Stephen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.