Investigating how humanized mice respond to HIV-1 vaccines
Official title: Characterizing antibody responses to HIV-1 vaccination in next-generation immune humanized mice
Funded at Vanderbilt University Medical Center · NIH-11041167 · Data updated 2026-11-12
This study is looking at how to make better HIV-1 vaccines by using special mice that have human-like immune systems, so researchers can learn how to boost the immune response to the vaccine and find ways to help people in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | March 21, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $389,277 |
| NIH project number | 5R01AI176521-03 |
| Project ID | NIH-11041167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of HIV-1 infection who may benefit from future vaccine developments.
✕Less likely to help
Patients who are already living with HIV or those who do not have a risk of HIV-1 infection may not benefit from this research.
What this research studies
This research focuses on improving the development of effective vaccines against HIV-1 by using a specialized type of mouse that has a human immune system. The study aims to enhance the immune response to HIV-1 vaccines by promoting better interactions between human T cells and B cells in these mice. By understanding how these humanized mice respond to vaccination, researchers hope to identify strategies that could lead to successful vaccine development for humans. The approach involves using advanced mouse models that can mimic human immune responses more accurately than traditional animal models.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines that prevent HIV-1 infection in humans.
How similar studies have gone: Previous research has shown promise in using humanized mouse models for studying HIV, but this specific approach is novel and aims to address existing limitations.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Goettel, Jeremy Allen — Vanderbilt University Medical Center
- Study coordinator: Goettel, Jeremy Allen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.