Investigating how human pancreatic cells regenerate over time
Single-cell longitudinal analysis of regeneration in human pancreatic slices
This study is looking at how certain cells in the pancreas can grow and turn into insulin-producing cells, which could help people with diabetes, by using special techniques to see how this process works in a lab setting.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10677724 on NIH RePORTER |
What this research studies
This research focuses on understanding the regeneration of pancreatic cells, particularly in individuals with diabetes. By isolating specific progenitor-like cells from human pancreatic slices, the team aims to observe how these cells can proliferate and differentiate into functional insulin-producing beta cells. The study utilizes advanced techniques, including single-cell RNA sequencing and long-term culture of pancreatic slices, to track the regeneration process in a controlled environment that mimics the human pancreas. This approach could provide insights into potential therapies for diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Type 1 or Type 2 diabetes who are over 21 years old.
Not a fit: Patients without diabetes or those who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance pancreatic regeneration and improve insulin production in diabetic patients.
How similar studies have performed: Other research has shown promise in similar approaches to studying pancreatic regeneration, indicating potential for success in this area.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Dominguez-Bendala, Juan — University of Miami School of Medicine
- Study coordinator: Dominguez-Bendala, Juan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.