Investigating how human coronaviruses infect the nasal lining
Human coronavirus infection of the nasal epithelium
This study is looking at how different coronaviruses, including the one that causes COVID-19, infect the cells in your nose, using samples from over 1,000 people to help find better ways to treat respiratory illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10886757 on NIH RePORTER |
What this research studies
This research focuses on understanding how different human coronaviruses, including the one responsible for COVID-19, infect the nasal epithelium. By using a collection of nasal epithelial cells from over 1000 individuals, the researchers will grow these cells in a laboratory setting to mimic the nasal environment. This approach allows them to study how these viruses behave and interact with the immune system, particularly in the context of the upper respiratory tract. The findings could provide insights into the mechanisms of infection and potential treatments for respiratory illnesses caused by coronaviruses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been infected with or are at risk of infection from coronaviruses, particularly those with respiratory symptoms.
Not a fit: Patients who are not affected by respiratory illnesses or who have no history of coronavirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for COVID-19 and other respiratory infections.
How similar studies have performed: Previous research has shown success in studying other coronaviruses, but this specific approach to understanding nasal epithelium infection is relatively novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Weiss, Susan R — University of Pennsylvania
- Study coordinator: Weiss, Susan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.