Investigating how HSF1 affects cancer growth by suppressing AMPK
A transcription-independent role of HSF1 in tumorigenesis via suppression of AMPK
This study is looking at how a protein called HSF1 affects cancer growth by interacting with another protein, AMPK, which helps protect against cancer, and it aims to find new ways to treat cancer by understanding how these proteins work together in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project ID | NIH-10650751 on NIH RePORTER |
What this research studies
This research explores the role of heat shock factor 1 (HSF1) in cancer development, particularly how it interacts with AMP-activated protein kinase (AMPK) to influence tumor growth. The study aims to uncover the mechanisms by which HSF1 inhibits AMPK, which is known to play a protective role against cancer. By using advanced laboratory techniques, researchers will analyze how HSF1 affects cellular processes related to fat and cholesterol metabolism that are linked to malignancy. This could lead to new insights into potential therapeutic targets for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with malignancies, particularly those with tumors influenced by metabolic processes.
Not a fit: Patients with non-malignant conditions or those whose tumors are not affected by metabolic pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating various cancers by targeting the pathways involved in tumor growth.
How similar studies have performed: While the specific approach of targeting HSF1's role in AMPK suppression is novel, similar research has shown promise in understanding metabolic pathways in cancer.
Where this research is happening
Toledo, United States
- University of Toledo Health Sci Campus — Toledo, United States (Active)
Researchers
- Principal investigator: Su, Kuo-Hui — University of Toledo Health Sci Campus
- Study coordinator: Su, Kuo-Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.