Investigating how HPV genomic features affect cervical cancer treatment response and recurrence.
HPV genomic structure in cervical cancer radiation response and recurrence detection
This study is looking at how certain features of the HPV virus can help doctors understand how well treatment works for women with advanced cervical cancer, so they can better predict who might need extra support during their care.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11085982 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of HPV genomic structures in the response to chemoradiation therapy for locally advanced cervical cancer. By identifying specific biomarkers before and after treatment, the study aims to predict which patients are at higher risk of treatment failure and recurrence. The researchers will analyze HPV genotypes and their alternative splicing patterns, as well as use advanced imaging techniques to monitor treatment effectiveness. This approach could lead to more personalized treatment strategies for cervical cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with locally advanced cervical cancer who are undergoing chemoradiation therapy.
Not a fit: Patients with early-stage cervical cancer or those who are not receiving chemoradiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting treatment outcomes and recurrence in cervical cancer patients, ultimately enhancing survival rates.
How similar studies have performed: Previous research has shown promise in using genomic and biomarker approaches to improve cancer treatment outcomes, indicating that this study builds on established methodologies.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Zhang, Jin — Washington University
- Study coordinator: Zhang, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.