Investigating how HPV genomic features affect cervical cancer treatment response and recurrence.
Official title: HPV genomic structure in cervical cancer radiation response and recurrence detection
Funded at Washington University · NIH-11085982 · Data updated 2026-11-12
This study is looking at how certain features of the HPV virus can help doctors understand how well treatment works for women with advanced cervical cancer, so they can better predict who might need extra support during their care.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $501,859 |
| NIH project number | 5R37CA279596-03 |
| Project ID | NIH-11085982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with locally advanced cervical cancer who are undergoing chemoradiation therapy.
✕Less likely to help
Patients with early-stage cervical cancer or those who are not receiving chemoradiation therapy may not benefit from this research.
What this research studies
This research focuses on understanding the role of HPV genomic structures in the response to chemoradiation therapy for locally advanced cervical cancer. By identifying specific biomarkers before and after treatment, the study aims to predict which patients are at higher risk of treatment failure and recurrence. The researchers will analyze HPV genotypes and their alternative splicing patterns, as well as use advanced imaging techniques to monitor treatment effectiveness. This approach could lead to more personalized treatment strategies for cervical cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting treatment outcomes and recurrence in cervical cancer patients, ultimately enhancing survival rates.
How similar studies have gone: Previous research has shown promise in using genomic and biomarker approaches to improve cancer treatment outcomes, indicating that this study builds on established methodologies.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Zhang, Jin — Washington University
- Study coordinator: Zhang, Jin
Related research
Other NIH-funded projects on the same topics.
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HPV genetic patterns that influence how cervical cancer responds to radiation and reveal early recurrence
This project looks at HPV genetic patterns in people with locally advanced cervical cancer to find markers that predict how they will respond to chemoradiation and to detect recurrence earlier.
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Keloid recurrence study using multi-omics in diverse patients
A research effort will look at why keloids come back after surgery, especially in African American patients, using comprehensive molecular data from patient samples.
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Community and digital tools to reduce HPV and cervical cancer burden
A nurse or health team will test a community-based, digital strategy to help girls and young women, especially in rural areas, get HPV vaccination and cervical cancer prevention services.
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Community and digital tools to reduce HPV and cervical cancer in women with HIV
A community- and digital-technology program aims to help girls and young women, including those with HIV, get more HPV vaccination and cervical cancer prevention services.
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mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
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Globally useful predictor for cervical cancer treatment response
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.