Investigating how HPV genes cause mutations linked to cervical cancer
Official title: Defining the ability of HPV oncogenes to promote mutagenesis
Funded at Kansas State University · NIH-10894615 · Data updated 2026-11-12
This study is looking at how certain HPV genes might cause changes in our DNA that can lead to cervical cancer, and it’s for anyone interested in understanding how HPV affects the body and contributes to cancer development.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kansas State University NIH-funded |
| Lab location | 1 site (Manhattan, United States) |
| Project start | July 27, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $190,000 |
| NIH project number | 5R21AI173784-02 |
| Project ID | NIH-10894615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with persistent HPV infections, particularly those at risk for developing cervical cancer.
✕Less likely to help
Patients who do not have HPV infections or those with cervical cancer unrelated to HPV may not benefit from this research.
What this research studies
This research explores the role of HPV oncogenes, specifically E6 and E7, in causing mutations that lead to cervical cancer. It examines whether these genes actively disrupt DNA repair processes or passively degrade tumor suppressors like p53 and RB. By analyzing how HPV influences the repair of DNA double-strand breaks, the research aims to determine if HPV makes these repairs more error-prone, potentially leading to cancer. The findings could provide insights into the mechanisms of HPV-related tumorigenesis.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cervical cancer development and potential new strategies for prevention or treatment.
How similar studies have gone: While the role of HPV in cervical cancer is well-established, the specific mechanisms of how HPV oncogenes promote mutagenesis are still being explored, making this research a novel investigation.
Where this research is happening
-
Kansas State University
Manhattan, United States Active
Researchers
- Principal investigator: Wallace, Nicholas a — Kansas State University
- Study coordinator: Wallace, Nicholas a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.