Investigating how HOXB13 affects prostate cancer progression
Official title: Comprehensive Analyses of HOXB13-regulated Transcriptional programs critical for Prostate Cancer Progression
Funded at Emory University · NIH-11031422 · Data updated 2026-11-12
This study is looking at how a gene called HOXB13 affects prostate cancer and why some treatments don’t work as well for certain patients, with the goal of finding better ways to help those with advanced prostate cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $477,455 |
| NIH project number | 5R01CA257446-05 |
| Project ID | NIH-11031422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are American men diagnosed with advanced prostate cancer, particularly those experiencing resistance to androgen-deprivation therapy.
✕Less likely to help
Patients with early-stage prostate cancer or those who do not have androgen-dependent prostate cancer may not benefit from this research.
What this research studies
This research focuses on understanding the role of the HOXB13 gene in prostate cancer, particularly how it influences the progression of the disease and resistance to standard treatments like androgen-deprivation therapy. The study aims to identify specific genes involved in tumor metastasis and how they interact with HOXB13, which may lead to new therapeutic targets. By analyzing the mechanisms of resistance in advanced prostate cancer, the research seeks to uncover potential strategies for improving treatment outcomes for patients. The approach includes examining gene interactions and their effects on cancer cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with advanced prostate cancer who have developed resistance to current therapies.
How similar studies have gone: Previous research has shown promising results in targeting gene interactions in prostate cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Yu, Jindan — Emory University
- Study coordinator: Yu, Jindan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.