Investigating how Hox genes influence motor neuron development
Understanding Hox epigenetic memory formation during motor neuron differentiation
['FUNDING_FELLOWSHIP'] · NEW YORK UNIVERSITY · NIH-10896752
This study is looking at how certain genes help shape the development of motor neurons, which are important for movement, by using special DNA technology to see how these genes turn on and off during early growth.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10896752 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how Hox genes, which are essential for early embryo development, regulate the differentiation of motor neurons. By utilizing advanced synthetic DNA technology, the study aims to explore the mechanisms that control the activation and repression of these genes during development. The approach involves inserting a synthetic Hox cluster into specific locations in the genome to analyze how these genes function in a controlled environment. This could provide insights into the epigenetic memory that influences gene expression during motor neuron formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions affecting motor neuron development or those interested in the underlying mechanisms of such conditions.
Not a fit: Patients with fully developed motor neuron functions and no genetic predisposition to related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for developmental disorders related to motor neuron dysfunction.
How similar studies have performed: Previous research has shown promise in understanding gene regulation through synthetic biology approaches, indicating potential success for this novel methodology.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAGIPANI, BHAVANA — NEW YORK UNIVERSITY
- Study coordinator: RAGIPANI, BHAVANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.