Investigating how host factors influence HIV latency and reactivation
Host factors regulating HIV latency and reactivation
This study is looking at how certain treatments can help keep HIV quiet in the body and prevent it from coming back when medication stops, which could lead to better ways to manage HIV for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10974038 on NIH RePORTER |
What this research studies
This research explores the role of host factors in regulating HIV latency and reactivation, focusing on the use of HIV transcriptional inhibitors as latency promoting agents. By combining antiretroviral therapy with specific inhibitors like didehydro-Cortistatin A and Spironolactone, the study aims to reduce residual HIV levels and prevent viral rebound when treatment is interrupted. The research employs both in vitro and in vivo models to understand how these agents can silence HIV without harming healthy cells. Patients may benefit from insights that could lead to more effective treatments for managing HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently undergoing antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for controlling HIV and potentially achieving a functional cure.
How similar studies have performed: Previous research has shown promise in using transcriptional inhibitors to manage HIV latency, indicating that this approach may be viable.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Valente, Susana T — University of Florida
- Study coordinator: Valente, Susana T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.