Investigating how host cell mechanisms can help keep HIV dormant in brain cells
Target Host Epigenetic Regulation of HIV Proviruses to Reinforce Viral Deep Latency in Microglia
This study is looking at how HIV can hide in brain cells even when people are on treatment, and it hopes to find new ways to help those living with HIV, especially if they have issues related to their brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11078753 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV can remain hidden in brain cells, specifically microglia, despite treatment with antiretroviral therapy. It aims to explore the role of epigenetic regulation, which involves changes in gene expression without altering the DNA sequence, in maintaining the virus's latency. By studying the molecular features that control HIV's persistent infection in these brain cells, the research seeks to identify potential strategies for better managing HIV in the central nervous system. This could lead to improved interventions for individuals living with HIV, particularly those experiencing neurological complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may experience neurological issues or have a history of HIV-associated neurocognitive disorders.
Not a fit: Patients who are not living with HIV or those who do not have neurological complications related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling HIV in the brain, potentially reducing neurological complications associated with the virus.
How similar studies have performed: While the approach of targeting epigenetic regulation in HIV latency is relatively novel, there have been promising findings in related areas of HIV research that suggest potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Zhu, Jian — Ohio State University
- Study coordinator: Zhu, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.