Investigating how hormones and the brain affect migraines differently in men and women.
Sex Differences in the Role of Gonadal Hormones and the Hypothalamus in Migraine with Aura.
This study is looking at how hormones and a part of the brain called the hypothalamus affect migraines with aura differently in men and women, with the hope of finding better treatments that take these differences into account.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10880501 on NIH RePORTER |
What this research studies
This research explores the differences between sexes in how gonadal hormones and the hypothalamus contribute to migraines with aura. Using advanced techniques like optogenetics and machine learning, the study aims to understand the underlying mechanisms of migraines, particularly focusing on how these factors vary between men and women. The research is conducted by a physician at Massachusetts General Hospital, who combines clinical expertise with innovative experimental methods to uncover new insights into migraine treatment. The ultimate goal is to develop targeted therapies that consider these sex differences.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who experience migraines with aura, particularly women, as they are disproportionately affected by this condition.
Not a fit: Patients who do not experience migraines or those with other types of headaches may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective migraine treatments tailored specifically for men and women.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in migraine mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Harriott, Andrea M — Massachusetts General Hospital
- Study coordinator: Harriott, Andrea M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.