Investigating how hormones affect inflammation in endometriosis
Official title: Hormonal Influences on Inflammation in Endometriosis
Funded at University of Texas Hlth Science Center · NIH-10991649 · Data updated 2026-11-12
This study is looking at how hormones and inflammation are connected in women with endometriosis, and it hopes to find genetic clues that could help improve treatment and management of the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 25, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $490,699 |
| NIH project number | 1R01HG013258-01A1 |
| Project ID | NIH-10991649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are reproductive-age women diagnosed with endometriosis, particularly those of European or Asian ancestry.
✕Less likely to help
Patients who do not have endometriosis or are outside the reproductive age range may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between hormonal influences and inflammation in endometriosis, a condition affecting many women. It aims to identify genetic factors that may link endometriosis with other inflammatory diseases. By utilizing advanced genetic studies and single-cell analysis, the research seeks to uncover immune pathways that are affected by hormonal changes. This could lead to a better understanding of how to manage and treat endometriosis effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for women suffering from endometriosis and related inflammatory conditions.
How similar studies have gone: Previous research has shown promising results in understanding the hormonal and inflammatory connections in endometriosis, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Lawrenson, Kate — University of Texas Hlth Science Center
- Study coordinator: Lawrenson, Kate
Related research
Other NIH-funded projects on the same topics.
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Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
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Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.