Investigating how hormones affect cognitive aging in women
Hormones & Behavior Core
['FUNDING_P01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11032842
This study is looking at how the hormone estradiol affects memory and thinking in older women, especially those with heart issues or weight concerns, by using female rodents to find out when it helps and when it might cause problems.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11032842 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the hormone estradiol influences cognitive aging in women, particularly under conditions like cardiovascular disease and obesity. By studying aging female rodents, the research aims to identify mechanisms that may cause estradiol to shift from being beneficial to potentially harmful for cognitive function. The project will establish a consistent rodent model of menopause and hormone therapy, and standardize behavioral tests to ensure reliable results across different studies. This coordinated approach will enhance the quality and reproducibility of the findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women experiencing cognitive decline or related health issues.
Not a fit: Patients who are not postmenopausal or do not have cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved hormone therapies that enhance cognitive function in aging women.
How similar studies have performed: Previous research has shown promising results in understanding hormone effects on cognitive function, making this approach both relevant and potentially impactful.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHRADER, LAURA — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: SCHRADER, LAURA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease and related dementia, Alzheimer's disease and related disorders, Alzheimer's disease or a related dementia, Alzheimer's disease or a related disorder, Alzheimer's disease or related dementia