Investigating how hormonal changes during perimenopause affect the risk of psychosis in women.
Hormonal Mechanisms of Perimenopausal Risk for Psychosis in Women
This study is looking at how changes in hormone levels during menopause might increase the risk of psychosis in women, and it's for women going through different stages of menopause who want to help us understand this important connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11015868 on NIH RePORTER |
What this research studies
This research focuses on understanding the heightened risk of psychosis that women experience during midlife, particularly during the perimenopausal transition. It aims to explore how changes in ovarian hormones during this critical period may contribute to this increased risk. By utilizing a comprehensive approach that includes behavioral assessments and daily symptom tracking over 35 days, the study will gather data from a diverse group of 750 women at different stages of menopause. This innovative methodology will help clarify the relationship between hormonal fluctuations and psychotic symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are in the perimenopausal stage and may be experiencing psychotic symptoms or are at risk for such symptoms.
Not a fit: Patients who are not experiencing perimenopausal symptoms or are male may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for women experiencing psychosis during midlife.
How similar studies have performed: While there is existing research on hormonal influences on psychosis during other reproductive events, this specific investigation into perimenopause is novel and has not been extensively studied.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Klump, Kelly L — Michigan State University
- Study coordinator: Klump, Kelly L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.