Investigating how homocysteine metabolism affects kidney disease in ADPKD
Role of homocysteine metabolism, endothelial function and microvascular rarefaction on renal disease severity and progression in ADPKD
This study is looking at how high levels of a substance called homocysteine might affect blood vessel health and make Autosomal Dominant Polycystic Kidney Disease (ADPKD) worse, with the hope of finding new ways to help improve kidney health for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10813002 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between homocysteine metabolism, endothelial function, and the progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD). It aims to explore how elevated levels of homocysteine, which can impair blood vessel function, contribute to the severity of kidney disease. By studying the mechanisms involved, the research seeks to identify potential therapeutic targets that could improve kidney health and slow disease progression. Patients may be involved in clinical trials assessing the effects of treatments that modulate homocysteine levels and endothelial function.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease (ADPKD), particularly those experiencing early stages of the disease.
Not a fit: Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of kidney disease in patients with ADPKD.
How similar studies have performed: Previous research has shown promising results in modulating homocysteine levels and improving endothelial function in related conditions, suggesting potential for success in this approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Irazabal, Maria V — Mayo Clinic Rochester
- Study coordinator: Irazabal, Maria V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.