Investigating how HMGA1 proteins influence colon cancer development
High Mobility Group A1 Chromatin Regulators in Colon Carcinogenesis
This study is looking at how a protein called HMGA1 might play a role in the growth of colorectal cancer, with the hope that understanding this could help find new ways to treat or prevent the disease for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10599596 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of High Mobility Group A1 (HMGA1) proteins in the development of colorectal cancer. The study aims to uncover the molecular mechanisms by which HMGA1 affects gene expression and contributes to tumor progression. By examining how HMGA1 is overexpressed in colorectal cancer compared to normal tissue, the research seeks to identify potential therapeutic targets. Patients may benefit from insights that could lead to new treatments or prevention strategies for colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with colorectal cancer or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of cancer unrelated to colorectal cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating colorectal cancer.
How similar studies have performed: Previous research has shown that targeting chromatin regulators like HMGA1 can impact cancer progression, indicating potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Resar, Linda M S — Johns Hopkins University
- Study coordinator: Resar, Linda M S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.