Investigating how HMGA1 proteins influence colon cancer development
High Mobility Group A1 Chromatin Regulators in Colon Carcinogenesis
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10421310
This study is looking at how a specific protein called HMGA1 might influence the growth of colorectal cancer, and it aims to find out what happens when this protein is turned off in lab models, which could help us understand cancer better and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10421310 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of High Mobility Group A1 (HMGA1) proteins in the development of colorectal cancer. It examines how these proteins affect gene expression and chromatin structure, which may lead to tumor progression. By silencing HMGA1 in preclinical models, researchers aim to determine its impact on cancer properties and stem cell behavior. The study utilizes advanced genetic techniques and animal models to explore these mechanisms in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with colorectal cancer or those at high risk for developing this disease.
Not a fit: Patients with non-colorectal cancers or those without any malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting HMGA1 to improve outcomes for colorectal cancer patients.
How similar studies have performed: Previous research has shown promising results in targeting chromatin regulators in cancer, indicating potential for success in this area.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RESAR, LINDA M S — JOHNS HOPKINS UNIVERSITY
- Study coordinator: RESAR, LINDA M S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers