Investigating how HIV treatment affects bone and fat health
Bone and fat cross-talk in antiretroviral therapy (ART) treated HIV patients
This study is looking at how certain HIV treatments can affect bone and fat health, helping us understand why some people might lose bone or gain fat while on these medications, so we can find better ways to support those living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10903838 on NIH RePORTER |
What this research studies
This research explores the effects of combination antiretroviral therapy (cART) on bone and fat health in individuals living with HIV. It aims to understand the hormonal communication between bone and fat tissues and how these interactions may lead to bone loss and fat gain in patients undergoing treatment. The study will utilize a combination of laboratory experiments, animal models, and human participant studies to investigate the mechanisms behind these comorbidities. By identifying the specific contributions of different antiretroviral medications, the research seeks to inform better treatment strategies for those affected.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently receiving combination antiretroviral therapy.
Not a fit: Patients who are not undergoing antiretroviral therapy or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that minimize bone loss and fat gain for patients living with HIV.
How similar studies have performed: Previous research has indicated that understanding the hormonal interactions between bone and fat can lead to significant advancements in managing comorbidities in chronic diseases, suggesting potential success for this approach.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Ross, Ryan Dee — Rush University Medical Center
- Study coordinator: Ross, Ryan Dee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.