Investigating how HIV RNA affects immune responses in people with HIV
RNA modification and innate immune activation in HIV infection
['FUNDING_R01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-10897531
This study is looking at how the presence of HIV in the body can keep the immune system active and cause ongoing inflammation in people living with HIV who are on treatment, with the goal of finding new ways to help improve their health and reduce complications like memory problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10897531 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of HIV RNA in causing chronic immune activation in individuals living with HIV who are on anti-retroviral therapy. It aims to explore how the presence of HIV RNA in the body contributes to ongoing inflammation and related complications, such as neurocognitive disorders. By examining the molecular mechanisms behind HIV RNA's effects, the study seeks to identify potential new therapeutic targets that could improve health outcomes for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on anti-retroviral therapy and experiencing HIV-associated non-AIDS complications.
Not a fit: Patients who are not living with HIV or those who are not on anti-retroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce chronic inflammation and improve the quality of life for people living with HIV.
How similar studies have performed: Other research has shown promising results in understanding the role of viral RNA in immune activation, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AKIYAMA, HISASHI — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: AKIYAMA, HISASHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus