Investigating how HIV-related particles affect brain blood vessel function
Official title: The effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvessels
Funded at Tulane University of Louisiana · NIH-10923300 · Data updated 2026-11-12
This study is looking at how tiny particles related to HIV might affect the blood-brain barrier and brain cell function, which could help explain memory and thinking problems in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | July 10, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $498,444 |
| NIH project number | 1R01NS136041-01A1 |
| Project ID | NIH-10923300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are experiencing cognitive difficulties or are at risk for neurocognitive disorders.
✕Less likely to help
Patients who are HIV-negative or those without any cognitive impairments related to HIV may not benefit from this research.
What this research studies
This research explores the impact of extracellular vesicles associated with HIV on the function of brain microvessels, which are crucial for maintaining the blood-brain barrier. It aims to understand how these vesicles contribute to mitochondrial dysfunction in brain cells, potentially leading to neurocognitive disorders in HIV-infected individuals. By using advanced imaging techniques, the study will analyze the effects of these vesicles on brain endothelial cells and their role in disrupting normal blood-brain barrier function. The findings could provide insights into the mechanisms behind cognitive impairments in patients with HIV.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent or treat neurocognitive disorders in HIV-infected patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of extracellular vesicles in various diseases, suggesting that this approach may yield valuable insights into HIV-related cognitive disorders.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Chandra, Partha — Tulane University of Louisiana
- Study coordinator: Chandra, Partha
Related research
Other NIH-funded projects on the same topics.
-
Center for Youth Equity: A Community Path to Prevent Youth Violence
A Tulane-led effort partners with communities to reduce youth violence by addressing racism, strengthening local youth voices, and building sustainable prevention strategies.
-
Breeding colony expansion to support HIV/AIDS research with rhesus macaques
A funding opportunity to expand a specialized Rhesus macaque breeding population to support HIV/AIDS research at Tulane’s primate facility.
-
HIV Resilience Observatory in a rhesus macaque colony expansion
A program to build a rhesus macaque breeding colony and use AI-powered monitoring to study why some HIV/AIDS outcomes differ among individuals with similar backgrounds.
-
Indoor-Outdoor Housing Expansion to Support HIV/AIDS-Related Research
A HIV-focused project at a primate research center will use new indoor/outdoor housing and AI-assisted monitoring to study why people with similar backgrounds can have very different HIV outcomes.
-
Whole-body and organ aging clocks from blood proteomics during calorie restriction
This project follows people in long-term calorie restriction studies to see how blood proteins reflect aging across the whole body and specific organs.
-
Unlocking new vaccine ideas by studying ETEC biofilms
A medical research project at Tulane aims to learn how ETEC bacteria form biofilms and how this could lead to a better vaccine for children in low- and middle-income countries.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.