Investigating how HIV-related particles affect brain blood vessel function
The effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvessels
This study is looking at how tiny particles related to HIV might affect the blood-brain barrier and brain cell function, which could help explain memory and thinking problems in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10923300 on NIH RePORTER |
What this research studies
This research explores the impact of extracellular vesicles associated with HIV on the function of brain microvessels, which are crucial for maintaining the blood-brain barrier. It aims to understand how these vesicles contribute to mitochondrial dysfunction in brain cells, potentially leading to neurocognitive disorders in HIV-infected individuals. By using advanced imaging techniques, the study will analyze the effects of these vesicles on brain endothelial cells and their role in disrupting normal blood-brain barrier function. The findings could provide insights into the mechanisms behind cognitive impairments in patients with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing cognitive difficulties or are at risk for neurocognitive disorders.
Not a fit: Patients who are HIV-negative or those without any cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent or treat neurocognitive disorders in HIV-infected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of extracellular vesicles in various diseases, suggesting that this approach may yield valuable insights into HIV-related cognitive disorders.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Chandra, Partha — Tulane University of Louisiana
- Study coordinator: Chandra, Partha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.