Investigating how HIV proteins contribute to heart and lung diseases in patients
Potential Role of Extracellular Vesicles for the Development of HIV Comorbidities
This study is looking at how HIV might increase the risk of heart and lung problems in people who are successfully treated with medication, by examining how certain HIV proteins can affect the body, with the goal of finding better ways to diagnose and treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10664903 on NIH RePORTER |
What this research studies
This research explores the connection between HIV and the increased risk of cardiovascular and pulmonary diseases in patients who are on effective anti-retroviral therapy. It focuses on how HIV proteins, particularly HIV-Nef, are released from cells and travel through extracellular vesicles, potentially causing damage and premature aging in the body. By studying these mechanisms in laboratory models, the research aims to identify specific markers and pathways that could lead to new diagnostic and therapeutic strategies for managing comorbidities in HIV patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-infected individuals who are on effective anti-retroviral therapy and are experiencing or at risk for cardiovascular or pulmonary diseases.
Not a fit: Patients who are not HIV-infected or those who do not have any comorbidities related to cardiovascular or pulmonary health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for HIV patients at risk of developing serious comorbidities.
How similar studies have performed: Other research has shown promising results in understanding the role of HIV proteins in disease progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Clauss, Matthias — Indiana University Indianapolis
- Study coordinator: Clauss, Matthias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.