Investigating how HIV persists in the brain and affects mental health.
CNS Viral Persistence and Neuropsychiatric Perturbations in HIV: Single cell and Molecular Interrogation
This study is looking at how HIV can stay in the brain even when people are on treatment and how that might affect thinking and mood, so if you’re living with HIV and want to understand more about its effects on your brain, this research could help!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11089382 on NIH RePORTER |
What this research studies
This research explores the persistence of HIV in the central nervous system (CNS) despite antiretroviral therapy (ART) and its impact on neuropsychiatric health. By analyzing cerebrospinal fluid and immune cells, the study aims to understand how HIV remains detectable in the brain and how this correlates with cognitive function. The researchers will use advanced techniques like single-cell transcriptomics to identify specific cell types and their roles in HIV infection. This approach may reveal critical insights into the mechanisms of HIV-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are on antiretroviral therapy and may experience cognitive difficulties.
Not a fit: Patients who are not living with HIV or those who do not have cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing cognitive impairments in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding HIV persistence in other tissues, but this specific focus on the CNS is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Spudich, Serena S — Yale University
- Study coordinator: Spudich, Serena S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.