Investigating how HIV persists and causes inflammation in the body
Official title: Understanding HIV-1 persistence and HIV-1-induced inflammation in tissues
Funded at Yale University · NIH-11117040 · Data updated 2026-11-12
This study is looking at how HIV stays in the body even when you're on treatment and how it can cause ongoing inflammation, which might lead to health issues like cancer and heart problems, with the goal of finding better ways to help people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 14, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $847,245 |
| NIH project number | 5R01AI183430-02 |
| Project ID | NIH-11117040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy but still experience health issues related to chronic inflammation.
✕Less likely to help
Patients who are not living with HIV or those who have not been on antiretroviral therapy may not benefit from this research.
What this research studies
This research focuses on understanding how HIV remains in the body despite treatment and how it causes ongoing inflammation. It examines the role of active HIV-infected cells in driving immune responses that can lead to accelerated aging and increased risks of diseases like cancer and cardiovascular issues. By studying these processes at a single-cell level, the research aims to uncover mechanisms that contribute to the persistence of HIV and its effects on health. This could lead to new strategies for improving treatment and outcomes for individuals living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce the long-term health risks associated with HIV, such as accelerated aging and increased cancer risk.
How similar studies have gone: Previous research has shown that understanding the mechanisms of HIV persistence and immune activation can lead to significant advancements in treatment strategies.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Ho, Ya-Chi — Yale University
- Study coordinator: Ho, Ya-Chi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.