Investigating how HIV persists and causes inflammation in the body
Understanding HIV-1 persistence and HIV-1-induced inflammation in tissues
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11117040
This study is looking at how HIV stays in the body even when you're on treatment and how it can cause ongoing inflammation, which might lead to health issues like cancer and heart problems, with the goal of finding better ways to help people living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11117040 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how HIV remains in the body despite treatment and how it causes ongoing inflammation. It examines the role of active HIV-infected cells in driving immune responses that can lead to accelerated aging and increased risks of diseases like cancer and cardiovascular issues. By studying these processes at a single-cell level, the research aims to uncover mechanisms that contribute to the persistence of HIV and its effects on health. This could lead to new strategies for improving treatment and outcomes for individuals living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy but still experience health issues related to chronic inflammation.
Not a fit: Patients who are not living with HIV or those who have not been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce the long-term health risks associated with HIV, such as accelerated aging and increased cancer risk.
How similar studies have performed: Previous research has shown that understanding the mechanisms of HIV persistence and immune activation can lead to significant advancements in treatment strategies.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HO, YA-CHI — YALE UNIVERSITY
- Study coordinator: HO, YA-CHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus