Investigating how HIV-infected T-cell exosomes contribute to lung cancer progression
(PQ1) HIV-infected T-cell exosomes in lung cancer progression
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10866524
This study is looking at how tiny particles released by HIV-infected cells might affect lung cancer growth in people living with HIV, and it hopes to find new ways to help treat lung cancer for these patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10866524 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of exosomes released by HIV-infected T cells in the progression of lung cancer. It aims to identify specific mechanisms by which these exosomes influence tumor growth and metastasis in individuals living with HIV. The study will analyze blood samples from lung cancer patients to explore how these exosomes affect lung cancer cell proliferation and the underlying biological pathways involved. By uncovering these interactions, the research seeks to provide insights into potential therapeutic targets for lung cancer in HIV-positive individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are at risk for or diagnosed with lung cancer.
Not a fit: Patients who do not have HIV or lung cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung cancer in patients living with HIV.
How similar studies have performed: Other research has shown promising results in understanding the role of exosomes in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIN, GE — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: JIN, GE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus