Investigating how HIV, certain medications, and cocaine affect brain inflammation and mental health.
Role of the NLRP3 Inflammasome in Mediating Microglial Activation and Development of Neuropsychiatric Symptoms Induced by HIV, Antiretrovirals and Cocaine
This study is looking at how HIV, its treatments, and cocaine use affect brain inflammation and mental health issues like anxiety and depression, to help find better ways to support people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-10878766 on NIH RePORTER |
What this research studies
This research explores the impact of HIV and its treatments, along with cocaine use, on brain inflammation and neuropsychiatric symptoms such as anxiety and depression. It focuses on the role of the NLRP3 inflammasome, a component of the immune response in the brain, in mediating these effects. By studying how these factors interact, the research aims to uncover the underlying mechanisms that contribute to neurological complications in people living with HIV. Patients may benefit from insights that could lead to improved treatments for mental health issues associated with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals over 21 years old who are living with HIV and may be experiencing mental health challenges.
Not a fit: Patients who are not living with HIV or who do not have neuropsychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for neuropsychiatric symptoms in individuals living with HIV.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways in the brain can lead to improvements in neuropsychiatric conditions, suggesting potential for success in this area.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Guo, Minglei — Old Dominion University
- Study coordinator: Guo, Minglei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.