Investigating how HIV and substance use affect brain cells over time
Single Chromatin Fiber Sequencing and Longitudinal Epigenomic Profiling in HIV+ Brain Cells Exposed to Narcotic and Stimulant
This study is looking at how HIV and drug use affect brain cells over time, hoping to learn more about why some people with HIV experience memory and thinking problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11045740 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of HIV and substance use disorders on brain cells by examining the chromatin structure and gene expression in these cells. The study aims to profile the epigenomic changes in HIV-infected brain cells longitudinally, which means it will track changes over time rather than just at one point. By analyzing brain tissue from individuals with HIV, the researchers hope to uncover how these factors contribute to neurocognitive disorders. This approach may provide insights into the molecular mechanisms that underlie cognitive decline in people living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of substance use disorders.
Not a fit: Patients who are HIV-negative or do not have any history of substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurocognitive disorders in individuals living with HIV.
How similar studies have performed: While there has been significant research on HIV and neurocognitive disorders, this specific longitudinal approach to studying chromatin changes in brain cells is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Akbarian, Schahram — Icahn School of Medicine at Mount Sinai
- Study coordinator: Akbarian, Schahram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.