Investigating how HIV and methamphetamine affect brain function using mini brain models.
Cerebral organoid and IPSC derived microglia: Modeling of HIV and methamphetamine co-morbidity
This study is looking at how HIV and methamphetamine affect brain health by creating tiny brain models from human cells, so we can better understand how these factors might lead to thinking problems for people living with HIV who use meth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10892205 on NIH RePORTER |
What this research studies
This research aims to understand the effects of HIV and methamphetamine on brain health by creating 3D models of the brain called cerebral organoids. These organoids are developed from human stem cells and can mimic the brain's structure and function. By studying these models, researchers hope to uncover how HIV and methamphetamine interact and contribute to brain disorders in affected individuals. This approach allows for a detailed examination of the underlying mechanisms that lead to cognitive issues in people living with HIV who also use methamphetamine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are living with HIV and have a history of methamphetamine use.
Not a fit: Patients who do not have HIV or a history of methamphetamine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive disorders in individuals living with HIV and methamphetamine use.
How similar studies have performed: While the specific combination of HIV and methamphetamine in cerebral organoids is novel, similar approaches using organoids to study brain diseases have shown promise in other contexts.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Yelamanchili, Sowmya — University of Nebraska Medical Center
- Study coordinator: Yelamanchili, Sowmya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.