Investigating how HIV and methamphetamine affect brain cells in a rodent model
Single nucleus gene expression in moderate and compulsive drug self-administration in a rodent model of HIV
['FUNDING_U01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-10993579
This study is looking at how HIV and long-term methamphetamine use affect brain cells, using special techniques on rats, to help us understand how these issues might lead to problems with drug addiction.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10993579 on ClinicalTrials.gov |
What this research studies
This research aims to understand the impact of HIV infection and chronic methamphetamine use on brain cells by using advanced techniques to analyze gene expression in specific brain regions of HIV transgenic rats. The study will differentiate between moderate and compulsive drug use patterns, which are crucial for understanding substance use disorders. By employing a voluntary drug self-administration model, researchers will observe how these factors contribute to neuroinflammation and neural injury. The findings could provide insights into the cellular mechanisms underlying the interaction between HIV and drug addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may also be experiencing issues related to methamphetamine use.
Not a fit: Patients who do not have HIV or are not involved in substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for individuals with HIV who also struggle with substance use disorders.
How similar studies have performed: Previous research has shown promising results in understanding the effects of drug use on HIV-infected populations, making this approach both relevant and potentially impactful.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANNA, PIETRO P — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: SANNA, PIETRO P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease