Investigating how HIV and its treatment affect the immune system in children and adolescents
The role of Trained Immunity and Mitochondrial dysfunction on INnate immunity in children and adolescents aGing with PHIV (TIMING-PHIV)
This study is looking at how living with HIV from birth and taking long-term medication affects the immune system of kids and teens in Uganda, to find ways to help them stay healthier even when their HIV is under control.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11040312 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of perinatally acquired HIV (PHIV) and long-term antiretroviral therapy (ART) on the immune system of children and adolescents. It examines how these factors may lead to persistent immune activation and dysfunction, even when HIV is well-managed. The study involves analyzing immune profiles in a cohort of adolescents in Uganda to identify differences between those living with HIV and those who are HIV-negative. By exploring the role of trained immunity and mitochondrial dysfunction, the research aims to uncover potential pathways for improving immune health in young individuals affected by HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 0-21 years who are living with perinatally acquired HIV.
Not a fit: Patients who are not living with HIV or who are outside the age range of 0-21 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing immune health in children and adolescents living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding immune dysfunction in HIV-infected populations, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Funderburg, Nicholas T. — Ohio State University
- Study coordinator: Funderburg, Nicholas T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.