Investigating how HIV and hepatitis B virus interact in liver cells
Official title: Primary cell culture models of HIV/HBV co-infection
Funded at Emory University · NIH-11072296 · Data updated 2026-11-12
This study is looking at how HIV and hepatitis B virus work together in liver cells to better understand their effects on liver health, especially for people who have both infections, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,814 |
| NIH project number | 3R21AI176944-02S1 |
| Project ID | NIH-11072296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are chronically infected with both HIV and HBV.
✕Less likely to help
Patients who are only infected with HIV or HBV, or those without any viral infections, may not benefit from this research.
What this research studies
This research focuses on understanding the complex interactions between HIV and hepatitis B virus (HBV) in liver cells, which is crucial for developing effective treatments. By creating primary cell culture models, researchers aim to study how these viruses co-infect and affect liver health, particularly in patients with chronic infections. The project seeks to explore the mechanisms that lead to severe liver complications, such as cirrhosis and cancer, in individuals with both infections. This approach may help identify new therapeutic strategies to combat these co-infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and potentially a cure for patients suffering from both HIV and HBV.
How similar studies have gone: Previous research has shown promise in understanding viral co-infections, but this specific approach using primary cell culture models is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Michailidis, Eleftherios — Emory University
- Study coordinator: Michailidis, Eleftherios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.