Investigating how HIV and hepatitis B virus interact in liver cells
Primary cell culture models of HIV/HBV co-infection
This study is looking at how HIV and hepatitis B virus work together in liver cells to better understand their effects on liver health, especially for people who have both infections, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11072296 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex interactions between HIV and hepatitis B virus (HBV) in liver cells, which is crucial for developing effective treatments. By creating primary cell culture models, researchers aim to study how these viruses co-infect and affect liver health, particularly in patients with chronic infections. The project seeks to explore the mechanisms that lead to severe liver complications, such as cirrhosis and cancer, in individuals with both infections. This approach may help identify new therapeutic strategies to combat these co-infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are chronically infected with both HIV and HBV.
Not a fit: Patients who are only infected with HIV or HBV, or those without any viral infections, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and potentially a cure for patients suffering from both HIV and HBV.
How similar studies have performed: Previous research has shown promise in understanding viral co-infections, but this specific approach using primary cell culture models is relatively novel.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Michailidis, Eleftherios — Emory University
- Study coordinator: Michailidis, Eleftherios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.