Investigating how HIV and cocaine affect brain inflammation and aging
Molecular mechanisms underlying HIV & Cocaine-mediated microglial activation: Targeting NLRP3 inflammasome
This study is looking at how HIV and cocaine use can cause brain inflammation, which might lead to memory problems like Alzheimer's, especially in people living with HIV as they get older, and it hopes to find new ways to help manage these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10846423 on NIH RePORTER |
What this research studies
This research explores the molecular mechanisms by which HIV and cocaine use activate microglial cells in the brain, leading to inflammation and potential neurodegenerative conditions like Alzheimer's disease. The study focuses on the NLRP3 inflammasome, a key player in the inflammatory response, and how it may contribute to the accumulation of toxic amyloid proteins in neurons. By examining brain samples and conducting cell culture experiments, the research aims to understand the interplay between HIV, cocaine, and neuroinflammation, particularly in individuals living with HIV who are experiencing age-related cognitive decline. This could provide insights into new therapeutic targets for managing these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who also have a history of cocaine use and are experiencing cognitive decline.
Not a fit: Patients who do not have HIV or a history of cocaine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate the cognitive decline associated with HIV and cocaine use.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuroinflammation in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Buch, Shilpa J. — University of Nebraska Medical Center
- Study coordinator: Buch, Shilpa J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.